If the report is confirmed on Sunday, using these stem cells will one day lead to better treatment of infertile women have left because of illness - or simply because they grow old.
"Our current understanding of ovarian aging are incomplete. There is much more than just a history of sewage from a fixed pool of eggs," said lead researcher Jonathan Tilly of Harvard Massachusetts General Hospital, which has long been hunted by these cells in a series of controversial research.
Previous work Tilley drew fierce skepticism, and independent experts urged caution on the latest discoveries.
The next important step is to any other laboratory test can be at work. If so, then it will take years of additional research to learn how to use the cells, says Teresa Woodruff, chief of fertility preservation in the Northwestern University Feinberg School of Medicine.
Nevertheless, the well-known critic said that such studies may help to dispel some of the mysteries surrounding the eggs mature and sustainable development of human birth.
"This will cause an increased interest, and most of all it gives us a new work," said David Albertini, Director of the University of Kansas Center for Reproductive Sciences. Although he has a lot of questions about the latest book: "I am less skeptical," he said.
Scientists have long understood that all female mammals are born with a finite supply of eggs, called ooctyes, which expires in middle age. Tilley, CEO of the mass of the reproductive biology, the first call of this concept in 2004, reported that in the ovaries of adult stem cells home to some of the eggs. Recently, Tilley said, a laboratory in China and one in the U.S. also reported the discovery of these rare cells in mice.
Do they exist in women? Enter the new work, reported on Sunday in Nature Medicine, the journal.
Tilley was first to find healthy people for the study of ovarian cancer. He has collaborated with scientists from the Saitama Medical University in Japan, which had been donated to freeze ovaries health research 20-something who underwent a sex change.
Tilly also had to respond to a review: How to tell if it was to find the real stem cells or eggs are just very immature. His team took hold of the protein is considered to sit on the surface only in stem cells and so-called recovered. To follow what happened next, the researchers inserted a gene that makes jellyfish glow green, some of these cells. If the cells in the eggs, glow Did those too.
"Bang, it worked - cells jumped straight out of" human tissue, Tilley said.
Researchers have observed in the microscope the eggs grown in a laboratory dish. Then came a key experience: they injected stem cells into pieces of human ovarian cancer. They transplanted human tissue under the skin of mice to provide a nourishing blood supply. Within two weeks, they said, control the formation of greenish eggs.
This is still a long way to show that they will ripen in use, the quality of eggs, said Albertini.
And much remains to be done to say exactly what these cells are reproductive biology warned Kyle Orwig of the University of Pittsburgh Medical Center, who oversaw the work of Tilly with great interest.
But if they are really competent stem cells, Orwig asked why women experience menopause? Indeed, something so rare, will not help a lot of natural reproductive function of women, said Woodruff Northwest.
Tilly argues that with the growth of egg stem cells in lab dishes in one day will help maintain fertility in cancer patients. Today the Woodruff laboratory and other parts to freeze ovarian female fertility before chemotherapy or radiotherapy to destroy. They learn how to persuade the immature eggs mature inside, so they can be used for in vitro fertilization years later, when the girls grew up. If it works, finally, Tilley said stem cells can become a better supply of eggs.
Down the road, he asked if she could also be possible to replenish the aging woman's ovaries.
A new study funded primarily by the National Institutes of Health. Tilly's co-founder, OvaScience Inc, to try to develop the results in the treatment of infertility.SOURCE
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